Id4 Marks Spermatogonial Stem Cells in the Mouse Testis

  title={Id4 Marks Spermatogonial Stem Cells in the Mouse Testis},
  author={Feng Sun and Qing Xu and Danfeng Zhao and Charlie Degui Chen},
  booktitle={Scientific reports},
Mammalian spermatogenesis is a classic adult stems cell-dependent process, supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs). However, the identification of SSCs and elucidation of their behaviors in undisturbed testis has long been a big challenge. Here, we generated a knock-in mouse model, Id4-2A-CreERT2-2A-tdTomato, which allowed us to mark Id4-expressing (Id4(+)) cells at different time points in situ and track their behaviors across distinct… CONTINUE READING