Id2a is required for hepatic outgrowth during liver development in zebrafish

@article{Khaliq2015Id2aIR,
  title={Id2a is required for hepatic outgrowth during liver development in zebrafish},
  author={Mehwish Khaliq and Tae-young Choi and Juhoon So and Donghun Shin},
  journal={Mechanisms of Development},
  year={2015},
  volume={138},
  pages={399-414}
}
During development, inhibitor of DNA binding (Id) proteins, a subclass of the helix-loop-helix family of proteins, regulate cellular proliferation, differentiation, and apoptosis in various organs. However, a functional role of Id2a in liver development has not yet been reported. Here, using zebrafish as a model organism, we provide in vivo evidence that Id2a regulates hepatoblast proliferation and cell death during liver development. Initially, in the liver, id2a is expressed in hepatoblasts… CONTINUE READING