Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells.

@article{Knell2013Id2ID,
  title={Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells.},
  author={Jamie Knell and John Adam Best and Nicholas A Lind and Edward Yang and Louise M D'Cruz and Ananda W Goldrath},
  journal={Journal of immunology},
  year={2013},
  volume={190 4},
  pages={1501-9}
}
CD8(+) T cells play a crucial role in the clearance of intracellular pathogens through the generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells that provide enhanced protection against reinfection. We have previously shown that the inhibitor of E protein transcription factors, Id2, is necessary for accumulation of effector and memory CD8(+) T cells during infection. In this study, we show that CD8(+) T cells lacking Id2 did not generate a robust… CONTINUE READING
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Repression of the DNAbinding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells

  • Y. Ji, Z. Pos, +7 authors P. Muranski
  • Nat. Immunol
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