Id2 and Id3 Inhibit Development of Cd34+ Stem Cells into Predendritic Cell (Pre-Dc)2 but Not into Pre-Dc1

@article{Spits2000Id2AI,
  title={Id2 and Id3 Inhibit Development of Cd34+ Stem Cells into Predendritic Cell (Pre-Dc)2 but Not into Pre-Dc1},
  author={Hergen Spits and Franka Couwenberg and Arjen Q. Bakker and Kees C Weijer and Christel H. Uittenbogaart},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={1775 - 1784}
}
We found previously that Id3, which inhibits transcriptional activities of many basic helix-loop-helix transcription factors, blocked T and B cell development but stimulated natural killer (NK) cell development. Here we report that ectopic expression of Id3 and another Id protein, Id2, strongly inhibited the development of primitive CD34(+)CD38(-) progenitor cells into CD123(high) dendritic cell (DC)2 precursors. In contrast, development of CD34(+)CD38(-) cells into CD4(+)CD14(+) DC1 precursors… CONTINUE READING

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