Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.

@article{Hara1994IdrelatedGE,
  title={Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.},
  author={Eiji Hara and Teruhide Yamaguchi and Hiroki Nojima and Tomohiro Ide and Judith Campisi and Hiroto Okayama and Kimimitsu Oda},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 3},
  pages={2139-45}
}
Three complete cDNA clones encoding Id-related helix-loop-helix (HLH) proteins lacking a basic region were isolated from a pcD2 cDNA expression library prepared from TIG-3 human diploid fibroblasts (HDF). Of these cDNAs (Id-1H, Id-1H', and Id-2H), two (Id-1H and Id-1H') appeared to be derived by alternative RNA splicing. Id-1H and Id-2H seem to be human homologues of mouse Id-1 and Id-2, respectively, and have potential to encode 154 and 135 amino acid proteins. The Id-1H and Id-2H mRNAs were… CONTINUE READING

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