Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells.

@article{Yang2013IdPA,
  title={Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells.},
  author={Jun Yang and Xiaohui Li and Ying Li and M Elaine Southwood and Lingying Ye and L. -K. Long and Rafia Al-Lamki and Nicholas W Morrell},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2013},
  volume={305 4},
  pages={L312-21}
}
Bone morphogenetic protein type II receptor (BMPR-II) mutations are responsible for over 70% of cases of heritable pulmonary arterial hypertension (PAH). Loss of BMP signaling promotes pulmonary vascular remodeling via modulation of pulmonary artery smooth muscle cell (PASMC) proliferation. Id proteins (Id1-4) are major downstream transcriptional targets of BMP signaling. However, the impact of BMPR-II mutation on the expression of the range of Id proteins and the contribution of individual Id… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…