Id proteins: small molecules, mighty regulators.

  title={Id proteins: small molecules, mighty regulators.},
  author={Flora Ling and Bin Kang and Xiao-Hong Sun},
  journal={Current topics in developmental biology},
The family of inhibitor of differentiation (Id) proteins is a group of evolutionarily conserved molecules, which play important regulatory roles in organisms ranging from Drosophila to humans. Id proteins are small polypeptides harboring a helix-loop-helix (HLH) motif, which are best known to mediate dimerization with other basic HLH proteins, primarily E proteins. Because Id proteins do not possess the basic amino acids adjacent to the HLH motif necessary for DNA binding, Id proteins inhibit… CONTINUE READING
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