Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression.

@article{Copp2004Id1AI,
  title={Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression.},
  author={Jean-Philippe Copp{\'e} and Yoko Itahana and D Helen Moore and James L. Bennington and P. Desprez},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 6},
  pages={2044-51}
}
PURPOSE Id proteins are dominant-negative regulators of basic helix-loop-helix transcription factors that control malignant cell behavior in many different tissues. This study aimed to identify the potential role of Id-1 and Id-2 proteins as molecular makers for prostate cancer progression. EXPERIMENTAL DESIGN Using the technique of immunohistochemistry, we determined Id-1 and Id-2 expression in a panel of 67 human prostate biopsies. We also manipulated Id-1 and Id-2 expression in LNCaP and… CONTINUE READING

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