Icsbp1/IRF-8 is required for innate and adaptive immune responses against intracellular pathogens.

@article{Turcotte2007Icsbp1IRF8IR,
  title={Icsbp1/IRF-8 is required for innate and adaptive immune responses against intracellular pathogens.},
  author={Karine Turcotte and Susan P Gauthier and Danielle Malo and Mifong Tam and Mary M Stevenson and Philippe Gros},
  journal={Journal of immunology},
  year={2007},
  volume={179 4},
  pages={2467-76}
}
The chronic myeloid leukemia syndrome of the BXH-2 mouse strain (Mus musculus) is caused by a recessive mutation (R294C) in the transcriptional regulator Icsbp1/IRF-8. In trans activation assays using an IL-12p40 gene reporter construct introduced in RAW 264.7 mouse macrophages, we show that the Icsbp1(C294) isoform behaves as a partial loss-of-function… CONTINUE READING