Iclaprim, a novel diaminopyrimidine for the treatment of resistant gram-positive infections.

@article{Sincak2009IclaprimAN,
  title={Iclaprim, a novel diaminopyrimidine for the treatment of resistant gram-positive infections.},
  author={Carrie A Sincak and J. Michael Schmidt},
  journal={The Annals of pharmacotherapy},
  year={2009},
  volume={43 6},
  pages={1107-14}
}
OBJECTIVE To review the pharmacology, microbiology, in vitro susceptibility, pharmacokinetics, clinical trial data, safety, and tolerability of iclaprim, a novel dihydrofolate reductase (DHFR) inhibitor. DATA SOURCES A MEDLINE search was conducted from 1966 through December 2008. Additional sources included abstracts from meetings of the Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Diseases Society of America from 2001 to 2008 and information available… CONTINUE READING