Icilin induces a hyperthermia in rats that is dependent on nitric oxide production and NMDA receptor activation.

@article{Ding2008IcilinIA,
  title={Icilin induces a hyperthermia in rats that is dependent on nitric oxide production and NMDA receptor activation.},
  author={Zhe Ding and Teresa Gomez and Jennifer L Werkheiser and A. A. Cowan and Scott Manning Rawls},
  journal={European journal of pharmacology},
  year={2008},
  volume={578 2-3},
  pages={201-8}
}
Icilin (AG-3-5) is a cold-inducing agent that activates the transient receptor potential channels TRPM8 and TRPA1. Both channels are members of the transient receptor potential (TRP) superfamily of ion channels and are activated by cold. Despite the key role of cold-activated TRPM8 and TRPA1 channels in temperature sensation and other physiological processes, the significance of these channels in thermoregulation in conscious animals is poorly understood. Therefore, in the present study we… CONTINUE READING
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