Icetexane diterpenoids from Perovskia atriplicifolia.

  title={Icetexane diterpenoids from Perovskia atriplicifolia.},
  author={Zhi-yong Jiang and Yi-jiang Yu and Chao-guan Huang and Xiang-zhong Huang and Qiu-fen Hu and Guangyu Yang and Hong-Bin Wang and Xiangyu Zhang and Gan-peng Li},
  journal={Planta medica},
  volume={81 3},
Five new icetexane diterpenoids, namely, perovskatones B-D (1, 3, 4), 1α-hydroxybrussonol (2), and 1α-hydroxypisiferanol (5), were isolated from Perovskia atriplicifolia, together with a new natural product (6) and two known compounds, przewalskin E (7) and brussonol (8). The structures of the new compounds were elucidated by detailed analyses of their MS, IR, 1D, and 2D NMR data. Compounds 1-8 were assayed for their inhibitory hepatitis B virus activities in the HepG 2.2.15 cell line. The… Expand
Two novel terpenoids from the cultured Perovskia atriplicifolia.
Two new terpenoids, named biperovskatone B and 1α- hydroxyl demethylsalvicanol quinine, were isolated from the cultured Perovskia atriplicifolia and showed noticeable anti- anti-HBV activity, inhibiting the replication of HBV DNA with IC50 values of 10.78 and 8.61 μM. Expand
Four New Diterpene Glucosides from Perovskia atriplicifolia
  • Lu Gao, Jun Zhou, +7 authors D. Xue
  • Chemistry, Medicine
  • Chemistry & biodiversity
  • 2017
Four new diterpene glucosides, namely perovskiaditerpenosides A – D (1 – 4), were isolated from the BuOH extract of Perovskia atriplicifolia and screened for their cytotoxic activity against HepG2, NB4, HeLa, K562, MCF7, PC3, and HL60. Expand
Diterpenes from an Uzbek medicinal plant Perovskia scrophulariifolia: Their structures and anti-neuroinflammatory activity.
The structures of new 20-norabietane diterpenes, perovsfolins C and D, were elucidated by spectroscopic analyses aided with calculations of ECD spectra and anti-neuroinflammatory activity of the isolated diter penes on microglial cells was evaluated. Expand
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A total of 175 abietane quinone diterpenes with ortho- or para-quinone chromophore, namely 11,12-ortho-quinone abietane, 11,14-para-quinone abietane, seco-abietane and abeo-abietanes quinones wereExpand
Collective Syntheses of Icetexane Natural Products Based on Biogenetic Hypotheses.
A divergent synthesis of 10 icetexane natural products based on a proposed biogenetic cationic ring expansion of a reduced carnosic acid derivative is described, and additional experimental evidence for the abiotic formation of the methylenedioxy unit is provided. Expand
Metabolomics and DNA-Based Authentication of Two Traditional Asian Medicinal and Aromatic Species of Salvia subg. Perovskia
It is demonstrated that DNA barcoding coupled with parallel LC-MS profiling constitutes a powerful tool in identification of taxonomically close Salvia species. Expand
Total Synthesis of (±)-Brussonol and (±)-Komaroviquinone via a Regioselective Cross-Electrophile Coupling of Aryl Bromides and Epoxides.
The short and stereoselective syntheses of diterpenes (±)-brussonol and (±-komaroviquinone, via a Ni-catalyzed epoxide ring-opening approach in the presence of aryl halides, is described to offer a unified route for the synthesis of several natural products containing icetexane motifs. Expand
Seasonal Variations of Rosmarinic Acid and Its Glucoside and Expression of Genes Related to Their Biosynthesis in Two Medicinal and Aromatic Species of Salvia subg. Perovskia
Two closely related medicinal and aromatic plants from Asia, called Russian sage or from their previously used Latin name–Perovskia, are studied to check if the composition of these plants is regulated by specific genes encoding proteins that assemble these phytochemicals, and two genes pointed out were linked to the regulation of rosmarinic acid biosynthesis. Expand
Anti-hepatitis B activities of Myanmar medicinal plants: a narrative review of current evidence.
This review summarizes the current evidence of Myanmar medicinal plants in basic and clinical research which shows promising potential for the development of novel therapeutic agents for the treatment of hepatitis B. Expand
Inhibition of Glycation-induced Cytotoxicity, Protein Glycation, and Activity of Proteolytic Enzymes by Extract from Perovskia atriplicifolia Roots
The extract from Perovskia atriplicifolia Benth, rich in rosmarinic acid, mitigated the glycatedalbumin toxicity, and increased glycated albumin-treated cell survival by more than 50%. Expand


Phytochemical investigation of Perovskia abrotanoides.
The phytochemical investigation of the n-hexane, the EtOAc, and then-BuOH soluble fractions of the methanolic extract of the arial parts of Perovskia abrotanoides Karelin furnished ten compounds including the two new tetracyclic diterpenes abrotandiol and abrotanone, whose complete structure elucidation has been achieved with NMR techniques. Expand
Three New Diterpenoids from Salvia przewalskii MAXIM
Three new compounds including one ortho-quinone-type icetexane diterpenoid, i.e., przewalskin E (1), one abietane dinorditerpenoid. i.e., przewalskin F (2), and one 7,20-epoxyabietane diterpenoid.Expand
A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis.
A new triterpenoid named alisol O was isolated from the rhizomes of Alisma orientalis, together with six known compounds, which exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2. Expand
Volatile Components of Perovskia atriplicifolia Benth
Abstract The essential oil isolated by steam distillation from the aerial parts of Perovskia atriplicifolia Benth. was analyzed by capillary GC and GC/MS. Among the 39 compounds identified, the majorExpand
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
The new diterpenes brussonol and iguestol with an icetexane and a dehydroabietane skeleton, respectively, have been isolated from hairy root cultures of Salvia broussonetii and investigated against the insect pests Spodoptera littoralis and Leptinotarsa decemlineata. Expand
Diterpenes from Salvia mellifera
Abstract Two new aromatic diterpenes have been obtained from the aerial part of Salvia mellifera and their structures identified, on the basis of spectral data and chemical correlations, asExpand
A new acylated steroid glucoside from Perovskia atriplicifolia.
Atroside (1), an acylated steroid glucoside, has been isolated from Perovskia atriplicifolia along with other known compounds.
Terpenoids from Isodon grandifolia var. Atuntzensis
Abstract Two new compounds, atuntzensin A and isodonsesquitin A, together with five known compounds, rosmanol, carnosol, 4′,7 -dimethylapigenin, ursolicacid and sitosterol were obtained from IsodonExpand
Biomimetic synthesis of grandione from demethylsalvicanol via hetero-Diels–Alder type dimerization and structure revision of grandione
Abstract Grandione, a unique isetexane diterpene dimer, was synthesized from demethylsalvicanol via the solid state hetero-Diels–Alder type dimerization reaction. By X-ray crystallography, grandioneExpand
Diterpenes from the roots of Salvia canariensis
The new diterpenes, deoxocarnosol 12-methyl ether, salvicanol and 6α-hydroxydemethylcryptojaponol have been isolated from the bark of the roots of Salvia canariensis. Expand