Icaritin inhibits PD‐L1 expression by Targeting Protein IκB Kinase α

@article{Mo2020IcaritinIP,
  title={Icaritin inhibits PD‐L1 expression by Targeting Protein I$\kappa$B Kinase $\alpha$},
  author={Dongliang Mo and Hai Zhu and Jun Wang and Haibang Hao and Yu-ming Guo and Jiaojiao Wang and Xuelian Han and Liangfeng Zou and Zhongwan Li and Hua Yao and Jinsong Zhu and Junma Zhou and Yong Peng and Jian Li and Kun Meng},
  journal={European Journal of Immunology},
  year={2020},
  volume={51},
  pages={978 - 988}
}
Icaritin, a small molecule currently being investigated in phase III clinical trials in China (NCT03236636 and NCT03236649) for treatment of advanced hepatocellular carcinoma (HCC), is a prenylflavonoid derivative obtained from the Epimedium genus. Previously, it was found that Icaritin decreased the expression of PD‐L1, but its direct molecular targets and the underlying mechanisms have not been identified. In this study, we report the identification of IKK‐α as the protein target of Icaritin… 
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TLDR
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