Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG.

@article{Zhai2014IcariinST,
  title={Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG.},
  author={Yuan-kun Zhai and Xiao-yu Guo and Bao-feng Ge and Ping Zhen and Xiao-ni Ma and Jian Zhou and Huiping Ma and Cory J Xian and Keming Chen},
  journal={Bone},
  year={2014},
  volume={66},
  pages={189-98}
}
Icariin, a prenylated flavonol glycoside isolated from Epimedii herba, has been found to be a potent stimulator of osteogenic differentiation and has potential application in preventing bone loss. However, the signaling pathway underlying its osteogenic effect remains unclear. We hypothesized that the osteogenic activity of icariin is related to the nitric oxide (NO) signal pathway and PI3K/AKT pathway in its upstream. Rat bone marrow stromal cells (rBMSCs) were cultured in osteogenic medium… CONTINUE READING
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