Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells.

@article{Mok2010IcariinPA,
  title={Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells.},
  author={Sao-keng Mok and Wen-Fang Chen and Wan-Ping Lai and Ping Chung Leung and Xin-luan Wang and Xinsheng Yao and Morette Wong},
  journal={British journal of pharmacology},
  year={2010},
  volume={159 4},
  pages={
          939-49
        }
}
BACKGROUND AND PURPOSE Icariin may be the active ingredient in Herba Epimedii, a Chinese herb commonly used for treatment of osteoporosis. The present study aims to delineate the mechanism(s) by which icariin prevents bone loss after ovariectomy (OVX) in vivo and stimulates osteoblastic functions in vitro. EXPERIMENTAL APPROACH Ovariectomized or sham-operated C57BL/6 mice were treated with vehicle, 17beta-oestradiol or icariin for 6 weeks. Total and trabecular bome mineral density (BMD) as… CONTINUE READING
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