Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERα-Wnt/β-catenin signaling pathway.

@article{Wei2016IcariinPO,
  title={Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERα-Wnt/β-catenin signaling pathway.},
  author={Qiushi Wei and Jin Zhang and Guoju Hong and Zhenqiu Chen and Weimin Deng and Wei He and Mei Hui Chen},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2016},
  volume={84},
  pages={931-939}
}
Icariin, the main effective component of Herba Epimedii, has been identified to regulate the osteogenic differentiation of rat bone marrow stromal cells (rBMSCs) and have potential application in preventing bone loss and promoting bone regeneration. However, the underlying signaling pathway of its osteogenic effect remains unclear. Here, we investigated whether icariin could promote osteogenesis of rBMSCs through modulating the estrogen receptor alpha (ERα) and Wnt/β-catenin signaling pathways… CONTINUE READING