Icariin promotes early and late stages of fracture healing in rats.

@article{Grbz2019IcariinPE,
  title={Icariin promotes early and late stages of fracture healing in rats.},
  author={Kaan G{\"u}rb{\"u}z and M{\"u}kerrem Bet{\"u}l Yerer and Perihan G{\"u}rb{\"u}z and Mehmet G{\"o}khan Halıcı},
  journal={Eklem hastaliklari ve cerrahisi = Joint diseases \& related surgery},
  year={2019},
  volume={30 3},
  pages={
          282-8
        }
}
OBJECTIVES This study aims to evaluate the effects of locally applied icariin on bone fracture healing in femur fractured rat model. MATERIALS AND METHODS The study included 64 male Sprague-Dawley rats (mean age 6 months; weighing, 280-490 g) in eight main study groups. Fracture healing process and level were evaluated with radiography, histopathology and dual energy X-ray absorptiometry to investigate the effects of local administration of icariin at varying doses, which is an exogenous… 
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References

SHOWING 1-10 OF 20 REFERENCES

Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis.

It is indicated that icariin has potential as a novel alternative therapeutic agent for fracture healing in postmenopausal osteoporosis.

The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats

It was unable to demonstrate any significant alterations in fracture biomechanics as measured by torsion testing and fracture stage in mature Sprague‐Dawley rats treated with 30 mg/kg/day oral dose of ibuprofen, starting 3 days following fracture, over a 12‐week time interval.

Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing.

The effect of icariin on bone metabolism and its potential clinical application

It is shown that icariin promotes bone formation by stimulating osteogenic differentiation of BMSCs (bone marrow-derived mesenchymal stem cells), while inhibiting osteoclastogenic differentiation and the bone resorption activity of osteoclasts.

Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone.

Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression.

Phytoestrogen-rich herb formula “XLGB” prevents OVX-induced deterioration of musculoskeletal tissues at the hip in old rats

Findings of this study suggested that the herbal preparation XLGB was able to prevent OVX-induced deterioration of musculoskeletal tissues at the hip without causing uterine stimulation.

Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line.

It is found that icariin significantly increased the cell viability, the activity of ALP and the amount of calcified nodules in the hFOB 1.19 human osteoblastic cell line and can modulate the process of bone formation via the BMP-2/Smad4 signal transduction pathway in hFOBs 1.

Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits.

Effects of icariin on the proliferation and differentiation of MC 3 T 3E 1

The effects of ICA on osteoblast differentiation from at least three perspectives are investigated to obtain an understanding of its mechanism of action and elucidate the molecular mechanisms of this drug, which might provide an insight into the rationality and in-depth theoretical basis for the clinical application of I CA in preventing osteoporosis.