Icariin promotes early and late stages of fracture healing in rats.

  title={Icariin promotes early and late stages of fracture healing in rats.},
  author={Kaan G{\"u}rb{\"u}z and M{\"u}kerrem Bet{\"u}l Yerer and Perihan G{\"u}rb{\"u}z and Mehmet G{\"o}khan Halıcı},
  journal={Eklem hastaliklari ve cerrahisi = Joint diseases \& related surgery},
  volume={30 3},
OBJECTIVES This study aims to evaluate the effects of locally applied icariin on bone fracture healing in femur fractured rat model. MATERIALS AND METHODS The study included 64 male Sprague-Dawley rats (mean age 6 months; weighing, 280-490 g) in eight main study groups. Fracture healing process and level were evaluated with radiography, histopathology and dual energy X-ray absorptiometry to investigate the effects of local administration of icariin at varying doses, which is an exogenous… 

Figures and Tables from this paper

Tetracalcium phosphate treatment on experimental fracture model in rats

Objectives This study aims to investigate the efficacy of tetracalcium phosphate (TTCP) on fracture healing in rat femurs. Materials and methods Forty-two female Wistar Albino rats were randomized

Systemic tranexamic acid promotes bone healing in a rat model of femur fracture

The use of systemic TXA accelerates early bone formation and fracture healing and shows a statistically significant difference between the 15-day mean score values in favor of the TXA group.

Can injection of adipose stem cells to non-union zone increase bone union? Experimental rat study

According to the results of the study, local adipose stem cell injection has positive radiological and histopathological effects in diabetic and non-diabetic femoral non-unions, independently of RANK, RANKL, or OPG gene expression pathways.

Biomimetic Calcium Phosphate Coating as a Drug Delivery Vehicle for Bone Tissue Engineering: A Mini-Review

This mini-review gives a brief introduction to BioCaP coatings regarding their preparation techniques, physicochemical properties, potential as a drug carrier, ability to suppress foreign body reactivity, and their preclinical application in ectopic and orthotopic models.

Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration

The article comprehensively reviewed the local application of TCM compounds to the materials in the bone regeneration in vitro and in vivo and found that icariin, naringin, quercetin, curcumin, berberine, resveratrol, ginsenosides, and salvianolic acids will contribute to the potential use ofTCM compound-loaded materials in BTE.



Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis.

It is indicated that icariin has potential as a novel alternative therapeutic agent for fracture healing in postmenopausal osteoporosis.

The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats

It was unable to demonstrate any significant alterations in fracture biomechanics as measured by torsion testing and fracture stage in mature Sprague‐Dawley rats treated with 30 mg/kg/day oral dose of ibuprofen, starting 3 days following fracture, over a 12‐week time interval.

The effect of icariin on bone metabolism and its potential clinical application

It is shown that icariin promotes bone formation by stimulating osteogenic differentiation of BMSCs (bone marrow-derived mesenchymal stem cells), while inhibiting osteoclastogenic differentiation and the bone resorption activity of osteoclasts.

Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression.

Phytoestrogen-rich herb formula “XLGB” prevents OVX-induced deterioration of musculoskeletal tissues at the hip in old rats

Findings of this study suggested that the herbal preparation XLGB was able to prevent OVX-induced deterioration of musculoskeletal tissues at the hip without causing uterine stimulation.

Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line.

It is found that icariin significantly increased the cell viability, the activity of ALP and the amount of calcified nodules in the hFOB 1.19 human osteoblastic cell line and can modulate the process of bone formation via the BMP-2/Smad4 signal transduction pathway in hFOBs 1.

Effects of icariin on the proliferation and differentiation of MC 3 T 3E 1

The effects of ICA on osteoblast differentiation from at least three perspectives are investigated to obtain an understanding of its mechanism of action and elucidate the molecular mechanisms of this drug, which might provide an insight into the rationality and in-depth theoretical basis for the clinical application of I CA in preventing osteoporosis.