Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line.

  title={Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line.},
  author={Wenna Liang and Mu-nan Lin and Xi-hai Li and Candong Li and Bizhen Gao and Huijuan Gan and Zhaoyang Yang and Xuejuan Lin and Linghong Liao and Min Yang},
  journal={International journal of molecular medicine},
  volume={30 4},
Icariin, the main active compound of the traditional Chinese medicine, Epimedium, is commonly used for the clinical treatment of osteoporosis. However, the precise molecular mechanism of the therapeutic effect of icariin has not been elucidated. The aim of this study was to examine the effect of icariin on cell viability, alkaline phosphatase (ALP) activity, the amount of calcified nodules, and to delineate the molecular mechanism of icariin-enhanced bone formation by investigating the… 

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