Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway.

@article{Zhang2012IcariinIC,
  title={Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway.},
  author={Hongying Zhang and Baojun Liu and Jinfeng Wu and Changqing Xu and Jiang Tao and Xiaohong Duan and Yuxue Cao and Jing-cheng Dong},
  journal={Molecular medicine reports},
  year={2012},
  volume={6 5},
  pages={967-72}
}
Excessive corticosterone (CORT) is acknowledged to induce neuronal damage in a number of regions of the brain, particularly the hippocampus, the main area implicated in depression. However, little research has been conducted on alterations to hypothalamic neurons in depression and the cellular and molecular basis for these changes. In the present study, we aimed to determine whether CORT causes apoptosis in primary cultured… CONTINUE READING

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