Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner.

@article{Zhao2008IcariinIO,
  title={Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner.},
  author={Jiyuan Zhao and Shinsuke Ohba and Masashige Shinkai and Ung-il Chung and Teruyuki Nagamune},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={369 2},
  pages={444-8}
}
To effectively treat bone diseases using bone regenerative medicine, there is an urgent need to develop safe cheap drugs that can potently induce bone formation. Here, we demonstrate the osteogenic effect of icariin, the main active compound of Epimedium pubescens. Icariin induced osteogenic differentiation in pre-osteoblastic MC3T3-E1 cells and mouse primary osteoblasts. Icariin upregulated the mRNA expression levels of the osteoblast marker genes runt-related transcription factor 2 (Runx2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

The experimental study of the effects of icariin on increasing smad4 mRNA level in MC3T3-E1 cell in vitro

  • Y. Xue, P. Wang, Q. Qi, H. Ni, X. Ma, S. Guo
  • Chin. J. Orthop. 25
  • 2005
2 Excerpts

Similar Papers

Loading similar papers…