Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats

@article{Pan2010IcariinAC,
  title={Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats},
  author={Ying Pan and Feihua Wang and Li-Qin Qiang and Dong-Mei Zhang and Lingzhi Kong},
  journal={Psychoneuroendocrinology},
  year={2010},
  volume={35},
  pages={272-283}
}
Chronic mild stress (CMS) is suggested to develop dysregulation of the limbic-hypothalamic-pituitary-adrenal (LHPA) stress circuit. Icariin, a major constituent of flavonoids isolated from Epimedium brevicornum, has been previously confirmed to rescue the HPA axis abnormalities in animal models of depression. However, antidepressant treatment of icariin on corticotropin-releasing factor (CRF) system within the LHPA stress circuit and its interaction with serotonergic receptor are still seldom… CONTINUE READING
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