Ibuprofen suppresses depressive like behavior induced by BCG inoculation in mice: role of nitric oxide and prostaglandin.

@article{Saleh2014IbuprofenSD,
  title={Ibuprofen suppresses depressive like behavior induced by BCG inoculation in mice: role of nitric oxide and prostaglandin.},
  author={Lobna A Saleh and May A Hamza and Nesreen H. El Gayar and Abeer A Abd El-Samad and Essam Amin Nasr and Somaia I Masoud},
  journal={Pharmacology, biochemistry, and behavior},
  year={2014},
  volume={125},
  pages={29-39}
}
Prostaglandins (PGs) and nitric oxide (NO) may be involved in the pathophysiology of depression. Since NSAIDs decrease PGs and NO production, they may have an antidepressant effect. The aim of the present work was to explore a possible antidepressant action of ibuprofen in the new model of Bacillus Calmette-Guerin (BCG) induced depression. Mice injected with BCG (10(7) CFU/mouse intraperitoneally) showed an increase in the total immobility time during the forced swim test (FST) and the tail… CONTINUE READING
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