Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.

  title={Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.},
  author={Ann C. McKee and Isabel Carreras and Lokman Hossain and Hoon Ryu and William L. Klein and Salvatore Oddo and Frank M Laferla and Bruce G. Jenkins and Neil W. Kowall and Alpaslan Dedeoglu},
  journal={Brain research},
We examined the effects of ibuprofen on cognitive deficits, Abeta and tau accumulation in young triple transgenic (3xTg-AD) mice. 3xTg-AD mice were fed ibuprofen-supplemented chow between 1 and 6 months. Untreated 3xTg-AD mice showed significant impairment in the ability to learn the Morris water maze (MWM) task compared to age-matched wild-type (WT) mice. The performance of 3xTg-AD mice was significantly improved with ibuprofen treatment compared to untreated 3xTg-AD mice. Ibuprofen-treated… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 66 extracted citations


Publications referenced by this paper.
Showing 1-10 of 81 references

Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.

The American journal of pathology • 2004
View 5 Excerpts
Highly Influenced

Dose-dependent pharmacokinetics of ibuprofen in the rat.

Drug metabolism and disposition: the biological fate of chemicals • 1987
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…