Ibuprofen protects low density lipoproteins against oxidative modification.

  title={Ibuprofen protects low density lipoproteins against oxidative modification.},
  author={Danuta Zapolska-Downar and A Zapolska-Downar and Hanna Bukowska and H Gałka and Marek Naruszewicz},
  journal={Life sciences},
  volume={65 22},
Oxidative modification of LDL by vascular cells has been proposed as the mechanism by which LDL become atherogenic. The effect of ibuprofen on LDL modification by copper ions, monocytes and endothelial cells was studied by measuring lipid peroxidation products. Ibuprofen inhibited LDL oxidation in a dose-dependent manner over a concentration range of 0.1 to 2.0 mM. Ibuprofen (2 mM, 100 microg/ml LDL) reduced the amount of lipid peroxides formed during 2 and 6 h incubation in the presence of… CONTINUE READING


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