Ibuprofen prevents deterioration in static transpulmonary compliance and transalveolar protein flux in septic porcine acute lung injury.

@article{Byrne1991IbuprofenPD,
  title={Ibuprofen prevents deterioration in static transpulmonary compliance and transalveolar protein flux in septic porcine acute lung injury.},
  author={K. E. Byrne and P. Declan Carey and Timothy D. Sielaff and J K Jenkins and Charles R. Blocher and K. R. Cooper and Alpha A Berry Fowler and Harvey J. Sugerman},
  journal={The Journal of trauma},
  year={1991},
  volume={31 2},
  pages={155-64; discussion 165-6}
}
UNLABELLED The effects of intravenous ibuprofen on measurements of pulmonary function and alveolar capillary membrane permeability to protein in sepsis-induced porcine acute lung injury (ALI) were studied. Young swine (15-25 kg) were anesthetized, cannulated, and ventilated (5 cm H2O PEEP, 0.5 FIO2, and 15 cc/kg tidal volume). Three groups were studied: septic animals (Ps, n = 10) received Pseudomonas aeruginosa for 1 hr IV, controls (C, n = 9) received 0.9% NaCl, and ibuprofen-treated septic… CONTINUE READING