Ibuprofen intervention in canine septic shock: reduction of pathophysiology without decreased cytokines.

@article{Coran1992IbuprofenII,
  title={Ibuprofen intervention in canine septic shock: reduction of pathophysiology without decreased cytokines.},
  author={Arnold G. Coran and Robert A. Drongowski and J J Paik and Daniel G Remick},
  journal={The Journal of surgical research},
  year={1992},
  volume={53 3},
  pages={272-9}
}
This study was undertaken to evaluate the effect of a cyclooxygenase inhibitor, ibuprofen, at various time intervals in a live Escherichia coli model of canine septic shock. Group I (control) animals (n = 5) received a LD100 dose of 10(9) live E. coli per kilogram were given no further treatment. Group II animals (n = 5) received a 10 mg/kg bolus of ibuprofen 10 min prior to bacterial infusion. Group III animals (n = 5) received ibuprofen 15 min after the bacterial infusion. Statistical… CONTINUE READING

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