Ibuprofen inhibits skeletal muscle hypertrophy in rats.

@article{Soltow2006IbuprofenIS,
  title={Ibuprofen inhibits skeletal muscle hypertrophy in rats.},
  author={Quinlyn Ann Soltow and Jenna Leigh Jones Betters and Jeff E. Sellman and Victor A Lira and Jodi Heather D. Long and David S. Criswell},
  journal={Medicine and science in sports and exercise},
  year={2006},
  volume={38 5},
  pages={
          840-6
        }
}
PURPOSE We sought to determine whether cyclooxygenase (COX) activity is necessary for overload-induced growth of adult rat skeletal muscle, and whether nitric oxide synthase (NOS) activity is involved in upregulation of COX messenger RNA (mRNA) expression in skeletal muscle. METHODS Unilateral surgical removal of the gastrocnemius and soleus was performed on the right hindlimb of 16 female Sprague-Dawley rats (approximately 230 g) to induce chronic overload (OL) of the plantaris for 14 d… CONTINUE READING
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