Ibuprofen inhibits granulocyte responses to inflammatory mediators. A proposed mechanism for reduction of experimental myocardial infarct size.

@article{Flynn1984IbuprofenIG,
  title={Ibuprofen inhibits granulocyte responses to inflammatory mediators. A proposed mechanism for reduction of experimental myocardial infarct size.},
  author={Patrick James Flynn and William K. Becker and Gregory Vercellotti and Daniel J. Weisdorf and Philip R. Craddock and Dale E. Hammerschmidt and Richard C. Lillehei and Harry S. Jacob},
  journal={Inflammation},
  year={1984},
  volume={8 1},
  pages={33-44}
}
The use of nonsteroidal antiinflammatory agents to reduce myocardial infarct size has demonstrated a dichotomy between ibuprofen, which reduces myocardial infarct size, and aspirin, which does not. A feline model of coronary ischemia using ligation of the anterior descending artery demonstrated that intravenous ibuprofen (2.5-20 mg/kg) given immediately and 2 h after ligation significantly decreased (by about 40%) myocardial infarct size. In contrast, aspirin did not diminish infarct size at… CONTINUE READING

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