Ibuprofen attenuates cardiac fibrosis in streptozotocin-induced diabetic rats.

Abstract

OBJECTIVE To investigate the effects of ibuprofen on cardiac fibrosis in a rat model of type 1 diabetes. METHODS The diabetic model was established by injecting streptozotocin into the rats. Then, ibuprofen or pioglitazone was given by gavage for 8 weeks. The cardiac fibrosis was assessed, and the major components of the renin-angiotensin system, the… (More)
DOI: 10.1159/000375362

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