Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia.

@article{Elsisi2005IbuprofenAA,
  title={Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia.},
  author={Nahed S Elsisi and Selina F. Darling-Reed and Eunsook Y Lee and Ebenezer T. Oriaku and Karam F A Soliman},
  journal={Neuroscience letters},
  year={2005},
  volume={375 2},
  pages={91-6}
}
In case of injury or disease, microglia are recruited to the site of the pathology and become activated as evidenced by morphological changes and expression of pro-inflammatory cytokines. Evidence suggests that microglia proliferate by cell division to create gliosis at the site of pathological conditions such as the amyloid plaques in Alzheimer's disease… CONTINUE READING