Ibuprofen Protects Platelet Cyclooxygenase from Irreversible Inhibition by Aspirin

@article{Rao1983IbuprofenPP,
  title={Ibuprofen Protects Platelet Cyclooxygenase from Irreversible Inhibition by Aspirin},
  author={Gundu H R Rao and Glenda G. Johnson and K. Raghunandan Reddy and J. G. White},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={1983},
  volume={3},
  pages={383–388}
}
  • G. Rao, G. Johnson, +1 author J. White
  • Published 1983
  • Chemistry, Medicine
  • Arteriosclerosis, Thrombosis, and Vascular Biology
Previous investigations have shown that ibuprofen inhibits the second wave of platelet aggregation and blocks the conversion of 14 C-arachidonic acid to thromboxane. However, the influence of the drug on platelet function and cyclooxygenase is transitory, lasting only 24 hours. The present study has taken advantage of the shortlived influence of ibuprofen to study its interaction with the long-term effects of aspirin. As expected, both aspirin and ibuprofen supressed platelet cyclooxygenase… Expand
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  • G. Rao, J. White
  • Chemistry, Medicine
  • Prostaglandins, leukotrienes, and medicine
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TLDR
Results of the studies suggest a common mechanism of action for these different classes of compounds, and each class of drug seems to have a relatively different effect upon platelet cyclooxygenase and function. Expand
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A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin
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TLDR
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Anti-inflammatory effects of aspirin and sodium salicylate.
TLDR
There is no common agreement about the extent to which salicylate contributes to aspirin's anti-inflammatory properties, as well as there is still no final conclusion reached about the mechanisms of action of sodium salicYLate. Expand
Pharmacology of platelet inhibition in humans: implications of the salicylate-aspirin interaction.
TLDR
The combination of salicylate with aspirin at an appropriate dose and blood level ratio may result in almost complete dissociation of the drug's effect on platelets and vessels in man. Expand
Enteric-coated aspirin, platelet cyclooxygenase activity and function.
TLDR
A single dose of slow releasing aspirin was as effective as fast acting regular aspirin in its effect on cyclooxygenase activity and platelet function in both human and canine platelets. Expand
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.
TLDR
The concomitant administration of ibuprofen but not rofecoxib, acetaminophen, or diclofenac antagonizes the irreversible platelet inhibition induced by aspirin, which may limit the cardioprotective effects of aspirin. Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Comparative effect of ibuprofen on endothelial and platelet prostaglandin synthesis.
TLDR
Ibuprofen showed no preferential inhibitory effect on TXA2 synthesis and, at a 100 microM concentration, was as effective as aspirin in the systems studied, suggesting that ib uprofen and aspirin might compete for binding by the cyclooxygenase. Expand
The effect of ibuprofen on platelet function in vivo.
  • Y. Ikeda
  • Medicine
  • The Keio journal of medicine
  • 1977
TLDR
The results may suggest that Ibuprofen is responsible for easy bruises in its users and the mechanism by which induces the platelet dys-function is somewhat different from that by aspirin. Expand
Indomethacin prevents the long-lasting inhibitory effect of aspirin on human platelet cyclo-oxygenase activity.
TLDR
Indomethacin and aspirin inhibit human platelet cyclo-oxygenase by the same basic mechanism, and acetylation of the enzyme appears to be a secondary mechanism which makes the inhibitory effect of aspirin persistent. Expand
Salicylate reverses in vitro aspirin inhibition of rat platelet and vascular prostaglandin generation.
TLDR
It is suggested that irreversible acetylation of cyclo-oxygenase does not account for the early in vitro inhibitory effect of aspirin on prostaglandin synthesis. Expand
Sulphinpyrazone prevents in vivo the inhibitory effect of aspirin on rat platelet cyclo-oxygenase activity.
TLDR
It is suggested that Sulphinpyrazone and its metabolites may interact with a binding site on cyclo-oxygenase not directly involved with the enzyme activity, which would be a prerequisite for its inhibitory effect on the enzyme active site. Expand
Effect of three nonsteroidal anti-inflammatory agents on platelet function and prostaglandin synthesis in vitro.
Abstract Effects on platelet aggregation in citrated, human, platelet-rich plasma (PRP) of nonsteroidal anti-inflammatory agents naproxen (Nap.), ibuprofen (Ib.) and aspirin (ASA) showed that theExpand
Inhibitory effect of ibuprofen (Motrin) on platelet function.
TLDR
Ibuprofen was found to be slightly more active than acetylsalicyclic acid as an inhibitor of collagen-induced platelet aggregation in human and rat PRP and it inhibited arachidonic acid-induced aggregation at much lower concentrations than those required to inhibit collagen- induced aggregation. Expand
Effect of acetaminophen and salicylate on aspirin-induced inhibition of human platelet cyclo-oxygenase.
TLDR
Results of the studies show that both drugs at equimolar concentrations had no inhibitory effect on aspirin induced blockage of cyclo-oxygenase or platelet function. Expand
Human platelet activation by an alkylacetyl analogue of phosphatidylcholine.
TLDR
The results do not support the concept that PAF is the mediator of the mechanism of membrane modulation through which epinephrine induces correction of the refractory state in prostaglandin I2-treated or dissociated platelets, or cells obtained from individuals following aspirin ingestion. Expand
Inhibition of platelet prostaglandin synthetase by oral aspirin.
TLDR
Platelet cyclooxygenase is more sensitive to inactivation by aspirin than enzyme in sheep seminal vesicles, which suggests that oral aspirin also inactivated megakaryocyte cyclo oxygengenase. Expand
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