Ibuprofen Protects Platelet Cyclooxygenase from Irreversible Inhibition by Aspirin

@article{Rao1983IbuprofenPP,
  title={Ibuprofen Protects Platelet Cyclooxygenase from Irreversible Inhibition by Aspirin},
  author={G. Rao and G. G. Johnson and K. Reddy and J. White},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={1983},
  volume={3},
  pages={383–388}
}
  • G. Rao, G. G. Johnson, +1 author J. White
  • Published 1983
  • Chemistry, Medicine
  • Arteriosclerosis, Thrombosis, and Vascular Biology
  • Previous investigations have shown that ibuprofen inhibits the second wave of platelet aggregation and blocks the conversion of 14 C-arachidonic acid to thromboxane. However, the influence of the drug on platelet function and cyclooxygenase is transitory, lasting only 24 hours. The present study has taken advantage of the shortlived influence of ibuprofen to study its interaction with the long-term effects of aspirin. As expected, both aspirin and ibuprofen supressed platelet cyclooxygenase… CONTINUE READING

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