Ibudilast modulates platelet-endothelium interaction mainly through cyclic GMP-dependent mechanism.

@article{Kishi2000IbudilastMP,
  title={Ibudilast modulates platelet-endothelium interaction mainly through cyclic GMP-dependent mechanism.},
  author={Y. Kishi and S. Ohta and N. Kasuya and M. Tatsumi and M. Sawada and S. Sakita and T. Ashikaga and F. Numano},
  journal={Journal of cardiovascular pharmacology},
  year={2000},
  volume={36 1},
  pages={
          65-70
        }
}
  • Y. Kishi, S. Ohta, +5 authors F. Numano
  • Published 2000
  • Medicine, Chemistry
  • Journal of cardiovascular pharmacology
  • 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (ibudilast) has been widely used in Japanese clinics for its antiasthmatic and antithrombotic effects. We investigated the mechanisms involved in the antiplatelet effects of the agent, specifically focusing on platelet-endothelium interaction. Ibudilast inhibits both phosphodiesterase (PDE) 3 and 5, the two major PDE isoforms of human platelets, with an IC50 of 31 and 2.2 microM, respectively. Cyclic guanosine monophosphate (GMP) accumulation in… CONTINUE READING
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