Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen.

@article{Bye2015IbrutinibIP,
  title={Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen.},
  author={Alexander P. Bye and Amanda J. Unsworth and Sakthivel Vaiyapuri and Alexander R. Stainer and Michael J. Fry and Jonathan M. Gibbins},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 11},
  pages={2326-35}
}
OBJECTIVE Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor approved for treatment of Waldenstrom macroglobulinemia, chronic lymphocytic leukemia, and mantle cell lymphoma that increases the risk of bleeding among patients. Platelets from ibrutinib-treated patients exhibit deficiencies in collagen-evoked signaling in suspension; however, the significance of this observation and how it relates to bleeding risk is unclear, as platelets encounter immobile collagen in vivo. We sought to… CONTINUE READING
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