Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells

@inproceedings{Chen2010IbrolipimIA,
  title={Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage-derived foam cells},
  author={Si-guo Chen and Ji Xiao and Xie-hong Liu and Mei-mei Liu and Zhong-cheng Mo and Kai Yin and Guo-jun Zhao and Jin Jiang and Li-bao Cui and Chun-zhi Tan and Wei-dong Yin and Chao-ke Tang},
  booktitle={Acta Pharmacologica Sinica},
  year={2010}
}
Aim:To determine the effects and potential mechanisms of ibrolipim on ATP-binding membrane cassette transporter A-1 (ABCA1) and ATP-binding membrane cassette transporter G-1 (ABCG1) expression from human macrophage foam cells, which may play a critical role in atherogenesis.Methods:Human THP-1 cells pre-incubated with ox-LDL served as foam cell models. Specific mRNA was quantified using real-time RT-PCR and protein expression using Western blotting. Cellular cholesterol handling was studied… CONTINUE READING

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