Ibogaine induces glial activation in parasagittal zones of the cerebellum.

@article{OHearn1993IbogaineIG,
  title={Ibogaine induces glial activation in parasagittal zones of the cerebellum.},
  author={Elizabeth E O'Hearn and Dan Long and Mark E. Molliver},
  journal={Neuroreport},
  year={1993},
  volume={4 3},
  pages={299-302}
}
Ibogaine, an indole alkaloid, has been proposed for treatment of drug addiction, yet its mechanism, site of action, and possible neurotoxicity have not been determined. Since neuronal injury is known to activate neurologlial cells, we investigated potential neurotoxic effects of this drug in rats by examining expression of specific glial markers. After treatment with ibogaine (100 mg kg-1 i.p.; 1-3 doses), we observed increased cytochemical markers in both microglia (OX-6, OX-42, W3/25) and… CONTINUE READING