Ibogaine antagonizes cocaine-induced locomotor stimulation in mice.

@article{Sershen1992IbogaineAC,
  title={Ibogaine antagonizes cocaine-induced locomotor stimulation in mice.},
  author={Henry W. Sershen and Audrey Hashim and L{\'a}szl{\'o} G{\'a}bor H{\'a}rsing and Abel Lajtha},
  journal={Life sciences},
  year={1992},
  volume={50 15},
  pages={
          1079-86
        }
}
Ibogaine (40 mg/kg i.p.), when given 2 hours before an acute injection of cocaine (25 mg/kg s.c.) to C57BL/6 mice, reduced the cocaine-induced locomotor stimulation. Such stimulation was also reduced in the ibogaine-treated mice when a second injection of cocaine was given 24 hr later. Thus, the reduction in locomotor activity was not just the short-term depression of locomotor activity seen after ibogaine administration. When mice were given a daily injection of cocaine for 3 days and ibogaine… CONTINUE READING
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