Ibogaine Therapy: A 'Vast, Uncontrolled Experiment'

  title={Ibogaine Therapy: A 'Vast, Uncontrolled Experiment'},
  author={Brian Vastag},
  pages={345 - 346}
  • B. Vastag
  • Published 15 April 2005
  • Psychology
  • Science
Despite potentially harsh side effects, an African plant extract is being tested in two public clinical trials--and many clandestine ones. 

Ibogaine-associated psychosis in schizophrenia: a case report.

Ibogaine is the main psychoactive molecule of a plant (Iboga) used for religious ceremonies and traditional initiation purposes in Gabon and is being considered for opioid addiction therapy in Western countries.

A phenomenological investigation into the lived experience of ibogaine and its potential to treat opioid use disorders

This study examined the lived experience of individuals who underwent ibogaine treatment for an opioid use disorder and probed for potentia in response to semi-structured interview questions.

Long-QT syndrome induced by the antiaddiction drug ibogaine.

A 31-year-old woman was admitted to the emergency department because of a seizure-like attack after a single 3.5-g dose of ibogaine. ECG showed a severe prolonged-QT interval of 548 msec and

Ibogaine in the treatment of substance dependence.

Concerns about ibogaine's safety, as well as a dearth of solid data from human studies, have hampered progress in its development as an approved medication, and major findings from preclinical studies are outlined.

Treating drug dependence with the aid of ibogaine: A retrospective study

A retrospective analysis of data from 75 previous alcohol, cannabis, cocaine and crack users suggests that ibogaine can be a safe and effective treatment for dependence on stimulant and other non-opiate drugs.

The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation

The aim of this review is to recapitulate the current knowledge about ibogaine’s effects on the heart and the cardiovascular system, and to assess the cardiac risks associated with the use of this drug in anti- addiction therapy.

The ibogaine medical subculture.

hERG Blockade by Iboga Alkaloids

Results may relate to observations of persistent QT prolongation and cardiac arrhythmia at delayed intervals of days following ibogaine ingestion, and suggest that the iboga alkaloids might provide an informative paradigm for investigation of the structural biology of the hERG channel.

Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes

Ibogaine was associated with substantive effects on opioid withdrawal symptoms and drug use in subjects for whom other treatments had been unsuccessful, and may provide a useful prototype for discovery and development of innovative pharmacotherapy of addiction.