Ibogaine Therapy: A 'Vast, Uncontrolled Experiment'

  title={Ibogaine Therapy: A 'Vast, Uncontrolled Experiment'},
  author={Brian Vastag},
  pages={345 - 346}
  • B. Vastag
  • Published 15 April 2005
  • Medicine
  • Science
Despite potentially harsh side effects, an African plant extract is being tested in two public clinical trials--and many clandestine ones. 
Ibogaine-associated psychosis in schizophrenia: a case report.
Ibogaine is the main psychoactive molecule of a plant (Iboga) used for religious ceremonies and traditional initiation purposes in Gabon and is being considered for opioid addiction therapy in Western countries. Expand
Ibogaine as a treatment for substance misuse: Potential benefits and practical dangers.
There is a need to develop better opiate detoxification treatment against a background of increasing opioid-related fatalities, and a congener of ibogaine, 18-MC, appears to be safer and is to undergo clinical trials. Expand
A phenomenological investigation into the lived experience of ibogaine and its potential to treat opioid use disorders
Background and aimsThis study examined the lived experience of individuals who underwent ibogaine treatment for an opioid use disorder.MethodsSemi-structured interview questions probed for potentia...
Long-QT syndrome induced by the antiaddiction drug ibogaine.
A 31-year-old woman was admitted to the emergency department because of a seizure-like attack after a single 3.5-g dose of ibogaine. ECG showed a severe prolonged-QT interval of 548 msec andExpand
Ibogaine in the treatment of substance dependence.
Concerns about ibogaine's safety, as well as a dearth of solid data from human studies, have hampered progress in its development as an approved medication, and major findings from preclinical studies are outlined. Expand
Treating drug dependence with the aid of ibogaine: A retrospective study
A retrospective analysis of data from 75 previous alcohol, cannabis, cocaine and crack users suggests that ibogaine can be a safe and effective treatment for dependence on stimulant and other non-opiate drugs. Expand
The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation
The aim of this review is to recapitulate the current knowledge about ibogaine’s effects on the heart and the cardiovascular system, and to assess the cardiac risks associated with the use of this drug in anti- addiction therapy. Expand
The ibogaine medical subculture.
The focus on opioid withdrawal in the ibogaine subculture distinguishes Ibogaine from other agents commonly termed "psychedelics", and is consistent with experimental research and case series evidence indicating a significant pharmacologically mediated effect of ibogane in opioid withdrawal. Expand
hERG Blockade by Iboga Alkaloids
Results may relate to observations of persistent QT prolongation and cardiac arrhythmia at delayed intervals of days following ibogaine ingestion, and suggest that the iboga alkaloids might provide an informative paradigm for investigation of the structural biology of the hERG channel. Expand
Breaking the cycle of opioid use disorder with Ibogaine
  • Deborah C Mash
  • Medicine
  • The American journal of drug and alcohol abuse
  • 2018
Two studies demonstrate that ibogaine may have significant pharmacological effects that include blockade of the acute signs and symptoms of opioid withdrawal (SOWS) and the post-acute withdrawal syndrome (cravings and depression). Expand