Ibogaine Therapy: A 'Vast, Uncontrolled Experiment'

@article{Vastag2005IbogaineTA,
  title={Ibogaine Therapy: A 'Vast, Uncontrolled Experiment'},
  author={Brian Vastag},
  journal={Science},
  year={2005},
  volume={308},
  pages={345 - 346}
}
  • B. Vastag
  • Published 15 April 2005
  • Psychology
  • Science
Despite potentially harsh side effects, an African plant extract is being tested in two public clinical trials--and many clandestine ones. 

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Results may relate to observations of persistent QT prolongation and cardiac arrhythmia at delayed intervals of days following ibogaine ingestion, and suggest that the iboga alkaloids might provide an informative paradigm for investigation of the structural biology of the hERG channel.

Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes

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Ibogaine was associated with substantive effects on opioid withdrawal symptoms and drug use in subjects for whom other treatments had been unsuccessful, and may provide a useful prototype for discovery and development of innovative pharmacotherapy of addiction.