Ibogaine Produces Neurodegeneration in Rat, but Not Mouse, Cerebellum

@article{Scallet1996IbogainePN,
  title={Ibogaine Produces Neurodegeneration in Rat, but Not Mouse, Cerebellum},
  author={Andrew C. Scallet and Xuemin Ye and Robert L. Rountree and Pascale Nony and S. Fatehyab Ali},
  journal={Annals of the New York Academy of Sciences},
  year={1996},
  volume={801}
}
  • A. Scallet, X. Ye, +2 authors S. Ali
  • Published 1996
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
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References

SHOWING 1-10 OF 26 REFERENCES
Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex
TLDR
Results are compatible with the idea that the ability of ibogaine and 12-hydroxyibogamine to interrupt drug-seeking behavior may, in part, result from their actions at the MK-801 binding site. Expand
Quantitative Morphometry for Neurotoxicity Assessment
Publisher Summary This chapter focuses on quantitative morphometry for neurotoxicity assessment. The application of quantitative morphometric methods to neurotoxicology is a relatively recentExpand
A preliminary investigation of ibogaine: case reports and recommendations for further study.
TLDR
Ibogaine, an alkaloid with psychotropic effects at doses of 200-300 mg and above, was taken by seven individuals who were addicted to opiates and may serve as a model for the development of improved agents for the treatment of substance abuse in the future. Expand
Ibogaine modulates cocaine responses which are altered due to environmental habituation: In vivo microvoltammetric and behavioral studies☆
TLDR
The data show a critical modulatory role for 5-HT in ibogaine-cocaine interactions and also elucidated as critical is the efficacy of Ibogaine when the response to (SC) cocaine is decreased due to the habituation of the animals to their environment. Expand
Ibogaine reduces preference for cocaine consumption in C57BL/6By mice
TLDR
Male C57BL/6By mice developed a preference for cocaine when given a choice of drinking either water or a solution containing cocaine (200 mg/l), and an acute challenge injection of cocaine produced a significant increase in cocaine-induced locomotor activity and stereotypy in mice previously exposed to cocaine in their drinking water (cocaine choice group. Expand
The inhibitory effect of norharman on morphine withdrawal syndrome in rats: Comparison with ibogaine
TLDR
It is concluded that both norharman and ibogaine are inhibitors of withdrawal syndrome in morphine-dependent rats. Expand
Degeneration of purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline
TLDR
It is concluded that both ibogaine and harmaline have selective neurotoxic effects which lead to degeneration of Purkinje cells in the cerebellar vermis. Expand
Ibogaine induces glial activation in parasagittal zones of the cerebellum.
TLDR
The ibogaine-induced activation of cerebellar glial cells is highly suggestive of neuronal degeneration, most likely of Purkinje cells. Expand
Inhibitory effects of ibogaine on cocaine self-administration in rats.
TLDR
The results indicate that ibogaine or its metabolite(s) is a long-lasting interruptor of cocaine dependence, which supports similar observations from uncontrolled clinical studies. Expand
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