Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures.

@article{Mash2000IbogaineCP,
  title={Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures.},
  author={Deborah C. Mash and Craig A. Kovera and Julio Pablo and Rachel F. Tyndale and F D Ervin and I C Williams and Edward G. Singleton and M Mayor},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={914},
  pages={
          394-401
        }
}
Ibogaine is an indole alkaloid found in the roots of Tabernanthe Iboga (Apocynaceae family), a rain forest shrub that is native to western Africa. Ibogaine is used by indigenous peoples in low doses to combat fatigue, hunger and thirst, and in higher doses as a sacrament in religious rituals. Members of American and European addict self-help groups have claimed that ibogaine promotes long-term drug abstinence from addictive substances, including psychostimulants and opiates. Anecdotal reports… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

  • Current neuropharmacology
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-8 OF 8 REFERENCES

Meta - analysis of cue - reactivity in addiction research

J. K. STALEY, J. PABLO, +3 authors K. C. RICE
  • 1999

Cytochrome P 4502 D 6 catalyzes the O - demethylation of the psychoactive alkaloid ibogaine to 12 - hydroxyibogamine

B. L. S. T. TIFFANY CARTER
  • Drug Metab . Dispos .
  • 1998

Identifi - cation of a primary metabolite of ibogaine that targets serotonin transporters and elevates serotonin

P. SHAPSHAK M. E. NORENBERG, W. L. HEARN, J. SANCHEZ-RAMOS
  • Pharmacol . Lett .
  • 1995

Identificaion and quantitation of ibogaine and an O - demethylated metabolite in brain and biological fluids using gas chromatography / mass spectrometry

R. P. ROTHMAN
  • J . Anal . Toxicol .
  • 1995

A preliminary investigation of ibogaine : case reports and recommendations for the further study

W. L. HEARN, G. HIME J. PABLO
  • J . Subst . Abuse Treat .
  • 1994

The development of a cocaine craving questionnaire

A. T. BECK, M. MENDELSON C. H. WARD
  • Drug Alcohol Depend .
  • 1993