Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.

@article{Benton2013IberiotoxinsensitiveA,
  title={Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.},
  author={Mark D Benton and Amanda H. Lewis and Jason S Bant and Indira M Raman},
  journal={Journal of neurophysiology},
  year={2013},
  volume={109 10},
  pages={2528-41}
}
Purkinje cells have specialized intrinsic ionic conductances that generate high-frequency action potentials. Disruptions of their Ca or Ca-activated K (KCa) currents correlate with altered firing patterns in vitro and impaired motor behavior in vivo. To examine the properties of somatic KCa currents, we recorded voltage-clamped KCa currents in Purkinje cell bodies isolated from postnatal day 17-21 mouse cerebellum. Currents were evoked by endogenous Ca influx with approximately physiological Ca… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 59 references

KCa channels as therapeutic targets in episodic ataxia type-2.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 4 Excerpts
Highly Influenced

Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2004
View 2 Excerpts
Highly Influenced

Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 4 Excerpts
Highly Influenced

Ionic mechanisms of burst firing in dissociated Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
View 4 Excerpts
Highly Influenced

Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
View 6 Excerpts
Highly Influenced

Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 4 Excerpts
Highly Influenced

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