Iatrogenic Effects of COX-2 Inhibitors in the US Population

@article{Vaithianathan2009IatrogenicEO,
  title={Iatrogenic Effects of COX-2 Inhibitors in the US Population},
  author={Rhema Vaithianathan and Peter M. Hockey and Thomas J. Moore and D. Bates},
  journal={Drug Safety},
  year={2009},
  volume={32},
  pages={335-343}
}
AbstractBackground: Selective cyclo-oxygenase 2 inhibitors (‘coxibs’) have been demonstrated to increase cardiovascular risk, but the cumulative burden of adverse effects in the US population is uncertain. Objective: To quantify cardiovascular and gastrointestinal (GI) haemorrhage disease burden from coxibs and traditional ‘non-selective’ non-steroidal anti-inflammatory drugs (t-NSAIDs) in the US population. Design, setting and participants: Adult respondents from the 1999–2003 Medical… 

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