Ian4 is required for mitochondrial integrity and T cell survival.

  title={Ian4 is required for mitochondrial integrity and T cell survival.},
  author={Malini Pandarpurkar and Leanne Wilson-Fritch and Silvia Corvera and Helle Markholst and Lars Hornum and Dale L. Greiner and John P. Mordes and Aldo A. Rossini and Rita Bortell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 18},
Apoptosis is a regulated cell death program controlled by extrinsic and intrinsic signaling pathways. The intrinsic pathway involves stress signals that activate pro-apoptotic members of the Bcl-2 family, inducing permeabilization of mitochondria and release of apoptogenic factors. These proteins localize to the outer mitochondrial membrane. Ian4, a mitochondrial outer membrane protein with GTP-binding activity, is normally present in thymocytes, T cells, and B cells. We and others have… CONTINUE READING
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Suppl. 1, 66A (abstr.)

  • R. D. Guttmann, E. Colle, F. Michel, T. Seemayer
  • J. Immunol
  • 1983

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