Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes

@article{Sun1986IarestrictedET,
  title={Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes},
  author={Deming Sun and Hartmut Wekerle},
  journal={Nature},
  year={1986},
  volume={320},
  pages={70-72}
}
T lymphocytes specific for myelin basic protein (MBP) are responsible for the cellular events leading to autoimmune disease within the central (CNS) and peripheral (PNS) nervous systems. Both in actively induced and T-cell transfer versions of experimental autoimmune encephalomyelitis (EAE) and neuritis (EAN), the autoaggressive T cells are activated outside the nervous system and reach their target tissue via the blood circulation. The target specificity of the autoaggressive T cells is… CONTINUE READING
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