IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity.

@article{Crow2003IVIgmediatedAO,
  title={IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity.},
  author={Andrew R. Crow and Seng Mi Song and John T. Freedman and Cheryl D. Helgason and Richard Keith Humphries and Katherine Anne Siminovitch and Alan H Lazarus},
  journal={Blood},
  year={2003},
  volume={102 2},
  pages={558-60}
}
It has been established that amelioration of murine immune thrombocytopenia purpura (ITP) by IVIg is dependent on the inhibitory receptor FcgammaRIIB. Co-cross-linking of the FcgammaRIIB with the B-cell receptor complex or with FcepsilonRI in mast cells results in cell inhibition, which is mediated by recruitment of the inositol phosphatase SHIP1 to the cytoplasmic tail of the FcgammaR. The FcgammaRIIB can also associate with protein tyrosine phosphatase SHP-1 as a potential secondary target of… CONTINUE READING
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