ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) is a new acute-phase protein isolated from cattle during experimental infection.

@article{Pieiro2004ITIH4I,
  title={ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) is a new acute-phase protein isolated from cattle during experimental infection.},
  author={M Pi{\~n}eiro and M Andr{\'e}s and M Iturralde and S Carmona and J Hirvonen and S Py{\"o}r{\"a}l{\"a} and P M H Heegaard and Kirsten Tj\orneh\oj and Ferm{\'i}n Lampreave and A Pi{\~n}eiro and Mar{\'i}a {\'A}ngeles {\'A}lava},
  journal={Infection and immunity},
  year={2004},
  volume={72 7},
  pages={3777-82}
}
We have isolated from calf serum a protein with an apparent M(r) of 120,000. The protein was detected by using antibodies against major acute-phase protein in pigs with acute inflammation. The amino acid sequence of an internal fragment revealed that this protein is the bovine counterpart of ITIH4, the heavy chain 4 of the inter-alpha-trypsin inhibitor family. The response of this protein in the sera was determined for animals during experimental bacterial and viral infections. In the bacterial… CONTINUE READING