ISOLATION OF SYNAPTIC VESICLES AND STRUCTURAL ORGANIZATION OF THE ACETYLCHOLINE SYSTEM WITHIN BRAIN NERVE ENDINGS *

@article{Robertis1963ISOLATIONOS,
  title={ISOLATION OF SYNAPTIC VESICLES AND STRUCTURAL ORGANIZATION OF THE ACETYLCHOLINE SYSTEM WITHIN BRAIN NERVE ENDINGS *},
  author={Eduardo de Robertis and G. Arnaiz and L. Salganicoff Amanda Pellegrino de Iraldi and Luis Marı́a Zieher},
  journal={Journal of Neurochemistry},
  year={1963},
  volume={10}
}
THE DISCOVERY of synaptic vesicles as the most significative component of nerve endings (DE ROBERTIS and BENNETT, 1954, 1955) led to the suggestion that they could be the site of storage and synthesis of transmitter substances. Since then this concept has become associated with the notion of a “quantized” release of acetylcholine at the neuromuscular junction (DEL CASTILLO and KATZ, 1956). At the same time several indirect indications of the role of these vesicles in synaptic transmission were… 
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  • 2004
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Since very little is known about the function and fate of these dense-cored vesicles and since the electric organ of electric rays as the source par excellence of cholinergic vesicle does not contain any, they have been neglected in the study of the biochemistry ofCholinergic synaptic transmission.
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