ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome

@article{Croft2000ISISTI,
  title={ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome},
  author={Larry J. Croft and Soeren Schandorff and Francis Clark and Kevin Burrage and Peter Arctander and John S. Mattick},
  journal={Nature Genetics},
  year={2000},
  volume={24},
  pages={340-341}
}
340 nature genetics • volume 24 • april 2000 In recent years, the discovery of many regulatory elements within introns, the recognition of the regulatory potential of intronic and other non-protein coding RNAs, and the concept of a cellular ‘ribotype’ resulting from differences in RNA processing in different cells and tissues have led to increasing interest in the role of introns in enhancing eukaryotic genetic complexity, via alternative splicing and as both the recipient and donor of cis… CONTINUE READING
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Nature America Inc. • http://genetics.nature.com © 2 00 0 N at u re A m er ic a In c. • h tt p :/ /g en et ic s

  • J Hanke
  • Trends Genet
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