ISG54 and ISG56 are induced by TLR3 signaling in U373MG human astrocytoma cells: possible involvement in CXCL10 expression.

@article{Imaizumi2014ISG54AI,
  title={ISG54 and ISG56 are induced by TLR3 signaling in U373MG human astrocytoma cells: possible involvement in CXCL10 expression.},
  author={Tadaatsu Imaizumi and Akiko Numata and Chikashi Yano and Hidemi Yoshida and Pengfei Meng and Ryo Hayakari and Fei Xing and Lian Wang and Tomoh Matsumiya and Kunikazu Tanji and Tetsuya Tatsuta and Manabu Murakami and Hiroshi Tanaka},
  journal={Neuroscience research},
  year={2014},
  volume={84},
  pages={34-42}
}
Toll-like receptor (TLR) 3 is a pattern recognition receptor that recognizes double-stranded RNA (dsRNA). TLR3 signaling in astrocytes leads to the expression of interferon-β (IFN-β), and IFN-β regulates immune and inflammatory reactions by inducing IFN-stimulated genes (ISGs). We demonstrated in the present study that polyinosinic-polycytidylic acid (poly IC), an authentic dsRNA, up-regulated the expression of ISG54 and ISG56 in U373MG human astrocytoma cells. This reaction was confirmed to be… CONTINUE READING