ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection.

Abstract

Conjugation of ISG15 inhibits replication of several viruses. Here, using an expression system for assaying human and mouse ISG15 conjugations (ISGylations), we have demonstrated that vaccinia virus E3 protein binds and antagonizes human and mouse ISG15 modification. To study ISGylation importance in poxvirus infection, we used a mouse model that expresses… (More)
DOI: 10.1128/JVI.03293-13

Topics

4 Figures and Tables

Cite this paper

@article{EduardoCorreia2014ISG15IC, title={ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection.}, author={Benedito Eduardo-Correia and Carles Mart{\'i}nez-Romero and Adolfo Garc{\'i}a-Sastre and Susana Guerra}, journal={Journal of virology}, year={2014}, volume={90 24}, pages={11280} }