ISG15: the immunological kin of ubiquitin.

  title={ISG15: the immunological kin of ubiquitin.},
  author={Kenneth J Ritchie and Dong-er Zhang},
  journal={Seminars in cell & developmental biology},
  volume={15 2},
Since the discovery of ubiquitin in 1975, the poly-ubiquitylation pathway has earned a prominent place in biomedical research as the "garbage disposal" system of the cell. Modification with poly-ubiquitin chains plays an important role in normal protein turnover and also in removing damaged or misfolded proteins. More recently, the elucidation of mono-ubiquitylation of protein substrates has shown additional important roles for ubiquitylation in processes, such as transcriptional regulation… CONTINUE READING

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